* *

**Second Edition Now
Available: Published August 2002 ISBN 0 471 49653 7**

*Cross-over Trials in Clinical Research* is the only book on the
subject written by someone who has designed and analysed
cross-over trials for a living. It is based on my extensive experience of
handling such trials during the eight years I worked for Ciba-Geigy in *seriously
*interested in the effects of treatments?'

Stephen Senn

**SAS, GenStat and S-Plus Programs**** to accompany the text.**

This is an excellent book on the understanding of the different facets of
crossover trials and their use in practical applications. J.R. Green, *JRSSA*.

Senn's book is a welcome and refreshing addition
to the literature on cross-overs which should be read
by all those interested in the subject. John Matthews, *Statistics in
Medicine*.

Oh that more frequentists were so eclectic, Andrew
Grieve, *The Statistician*.

This is a good practical book which is well presented and attractively laid
out. David Morgan, *Pharmaceutical
Journal*

Dem Autor ist est gelungen, die
Besonderheiten und Probleme der Planung und Auswertung von Cross-over-Studien
umfassend und in didkaktisch geschikter Weise darzustellen. *Die Pharmazeutische Industrie*.

This practical book is a good introduction to the controversial topic of
cross-over trials in pharmacological studies for both medical scientist and
statisticians. S.M. Lewis, *ISI Short Book Reviews *

This book provides a user-friendly, work-sheet approach to the analysis of
cross-over studies. James Bolognese, *Biopharmaceutical Report *

In summary, I found this a stimulating and enjoyable book to read and one
that is likely to prove to be extremely useful to many others in the area.
Philip North, *ISCB News.*

There is little doubt that Stephen Senn has
provided a much needed text to guide any researcher through the perils of
design, analysis and interpretation of such studies. A.O Hughes, *European
Respiratory Journal *

This book is essential reading for both doctors and other scientists engaged
in clinical research. John Ashford, *Journal of Drug Development *

This book will prove an invaluable reference to all statisticians and
researchers in the pharmaceutical industry. It will also appeal to physicians involved
in clinical research. *Biometrie-Praximitrie**
*

It contains a large number of practical examples using published clinical
trials. *Scrip Magazine *

Each chapter has excellent motivation and nice closure sections.....If
cross-over trials are pertinent to you, this book would be a fine choice for
your library. *Technometrics** *

**From the reviews of the second edition**

The intended audience for this text is both statisticians and medical
researchers. Professor Stephen Senn serves both these
audiences well by striking an excellent balance between appropriate technical
details and discussion. Michael Branson, *Applied Clinical Trials*

...I recommend this book for biologists and statisticians alike. It is an
excellent reference source and is easily readable. Alan S Rigby, *The** Statistician*

This
second edition includes several enhancements to the first edition. …The book is
clearly written and, generally, easy to follow. Each concept or analytic
approach is followed by a worked example using one or more computing packages,
as well as a discussion of the interpretation of the results. This mode of
presentation is very effective and appropriate for the target audiences. The
author also carefully justifies his choice of particular approaches. Julia A
Stoner, *Journal of the American
Statistical Association*

Preface

1. Introduction

2. Some basic considerations concerning estimation in
clinical trials

3. The AB/BA design with Normal Data

4. Other Outcomes and the AB/BA Design

5. Normal data from designs with three or more
treatments

6. Other outcomes from designs with three or more
treatments

7. Some special designs

8. Graphical and tabular presentation of cross-over trials

9. Various design issues

10. Mathematical approaches to carry-over. John
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