Second Edition Now Available: Published August 2002 ISBN 0 471 49653 7
Cross-over Trials in Clinical Research is the only book on the
subject written by someone who has designed and analysed
cross-over trials for a living. It is based on my extensive experience of
handling such trials during the eight years I worked for Ciba-Geigy in
SAS, GenStat and S-Plus Programs to accompany the text.
This is an excellent book on the understanding of the different facets of crossover trials and their use in practical applications. J.R. Green, JRSSA.
Senn's book is a welcome and refreshing addition to the literature on cross-overs which should be read by all those interested in the subject. John Matthews, Statistics in Medicine.
Oh that more frequentists were so eclectic, Andrew Grieve, The Statistician.
This is a good practical book which is well presented and attractively laid out. David Morgan, Pharmaceutical Journal
Dem Autor ist est gelungen, die
Besonderheiten und Probleme der Planung und Auswertung von Cross-over-Studien
umfassend und in didkaktisch geschikter Weise darzustellen.
This practical book is a good introduction to the controversial topic of cross-over trials in pharmacological studies for both medical scientist and statisticians. S.M. Lewis, ISI Short Book Reviews
This book provides a user-friendly, work-sheet approach to the analysis of cross-over studies. James Bolognese, Biopharmaceutical Report
In summary, I found this a stimulating and enjoyable book to read and one that is likely to prove to be extremely useful to many others in the area. Philip North, ISCB News.
There is little doubt that Stephen Senn has provided a much needed text to guide any researcher through the perils of design, analysis and interpretation of such studies. A.O Hughes, European Respiratory Journal
This book is essential reading for both doctors and other scientists engaged in clinical research. John Ashford, Journal of Drug Development
This book will prove an invaluable reference to all statisticians and researchers in the pharmaceutical industry. It will also appeal to physicians involved in clinical research. Biometrie-Praximitrie
It contains a large number of practical examples using published clinical trials. Scrip Magazine
Each chapter has excellent motivation and nice closure sections.....If cross-over trials are pertinent to you, this book would be a fine choice for your library. Technometrics
From the reviews of the second edition
The intended audience for this text is both statisticians and medical researchers. Professor Stephen Senn serves both these audiences well by striking an excellent balance between appropriate technical details and discussion. Michael Branson, Applied Clinical Trials
...I recommend this book for biologists and statisticians alike. It is an excellent reference source and is easily readable. Alan S Rigby, The Statistician
This second edition includes several enhancements to the first edition. …The book is clearly written and, generally, easy to follow. Each concept or analytic approach is followed by a worked example using one or more computing packages, as well as a discussion of the interpretation of the results. This mode of presentation is very effective and appropriate for the target audiences. The author also carefully justifies his choice of particular approaches. Julia A Stoner, Journal of the American Statistical Association
2. Some basic considerations concerning estimation in clinical trials
3. The AB/BA design with Normal Data
4. Other Outcomes and the AB/BA Design
5. Normal data from designs with three or more treatments
6. Other outcomes from designs with three or more treatments
7. Some special designs
8. Graphical and tabular presentation of cross-over trials
9. Various design issues
10. Mathematical approaches to carry-over. John Wiley & sons Page